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Association between melatonin secretion and nocturia in elderly individuals: A cross-sectional study of the HEIJO-KYO cohort

By K. Obayashi, K. Saeki and N. Kurumatani.

Journal of Urology, Volume 191, Issue 6, June 2014, Pages 1816-1821

Editor's comments:
The rationale of the present study comes from the observation that exogenous melatonin reduces urine production and increase bladder capacity in rats. Melatonin is a pineal gland hormone, whose secretion follows a diurnal rhythm with almost all production at night and shows a crucial role in nocturnal voiding regulation. Previous clinical trials suggested that oral administration of exogenous melatonin or its agonist decreases nocturia episodes. In the present study 861 individuals (mean age of 72 yrs) underwent the measurement of nocturnal void frequency and overnight urinary 6-sulfatoxymelatonin excretion, used as an index of melatonin secretion. The Authors found a significant association between nocturia and age, gender, body mass index, BPH, and urinary 6- sulfatoxymelatonin. In synthesis, melatonin secretion appeared to be inversely correlated with nocturia in old people.  The study strongly poses the basis for further development in the knowledge of nocturnal polyuria and in a more adequate and directed treatment possibilities.